Losing weight sooner rather than later gives best chance of reversing heart damage from obesity, according to mouse study

In a study of the impact of weight loss on reversing heart damage from obesity, researchers found that poor heart function in young obese mice can be reversed when the animals lose weight from a low-calorie diet. However, older mice, who had been obese longer, did not regain better heart function after they were on the same low-calorie diet.

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