Obesity in mothers alters babies' weight through brain rewiring

Obese mothers are more likely to have children with metabolic disorders, but the underlying reasons for this effect have been unclear. A new study reveals that the offspring of mouse mothers on a high-fat diet are predisposed to obesity and diabetes because of abnormal neuronal circuits in the hypothalamus. The findings suggest that mothers who consume a large amount of fat during the third trimester may be putting their children at risk for lifelong obesity.

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