Extended wakefulness is linked to injury to, and loss of, neurons that are essential for alertness and optimal cognition, the locus coeruleus neurons, a mouse model of chronic sleep loss has revealed. According to common wisdom, catch up sleep repays one's "sleep debt," with no lasting effects. But the new study shows disturbing evidence that chronic sleep loss may be more serious than previously thought and may even lead to irreversible physical damage to and loss of brain cells.
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